Pitfalls for career changer

Greetings all, Are there any unique issues for people making a career change into IT from other fields? I have worked in healthcare and education in the past. While gaining an advanced degree in healthcare, I gained a lot of transferable soft skills but realized the actual medical work was not for me. I have already identified a few things in my resume (not bad things) that would cause most HR reps to throw away my resume without a serious look. 1. The degree. Advanced degree not directly related to IT. 2. Prior positions that have paid slightly more. HR at least would assume I am going to grab a higher-pay position the next day. Do most hiring managers have the same prejudices? 3. Looking too smart for the job. While a smart hiring manager would see the value of a quick-learning and hard-working team member, not so sure the HR reps would see it that way. In your experience, are hiring managers more willing to give newcomers a chance? I keep hearing about HR reps who simply toss out all resumes received. I may just be making too much of this and over-analyzing. I am also willing to clarify any questions as needed. Thanks
Comments
2015 Start WGU (Feb) Net+ (Feb) Sec+ (Mar) Project+ (Apr) Other WGU (Jun) CCENT (Jul) CCNA (Aug) CCNA Security (Aug) MCP 2012 (Sep) MCSA 2012 (Oct) Linux+ (Nov) Capstone/BS (Nov) VCP6-DCV (Dec) ITILF (Dec)
2015 Start WGU (Feb) Net+ (Feb) Sec+ (Mar) Project+ (Apr) Other WGU (Jun) CCENT (Jul) CCNA (Aug) CCNA Security (Aug) MCP 2012 (Sep) MCSA 2012 (Oct) Linux+ (Nov) Capstone/BS (Nov) VCP6-DCV (Dec) ITILF (Dec)