The best anti-virus solution is a combination of at least two different av programs, for the obvious reasons that two know (hence can find) more than one. I prefer Trend Micro, their virus wall saved my @ss several times. At home I usually run a House call (free online scan) from trendmicro.
You said two, which is the other one? Trend Micro and?
I like AVG's minimalistic K.I.S.S approach. Simple small and seems to work well for detecting all the viruses out there. I wish they would team up with spybot S&D/ADaware and a good Trojan Detector. It would make a ultimate malware detection bundle.
i have an 18 year old sister...i used every AV you can think of ...and like clock work.....i have to reimage her machine every 4-6 weeks...i dont even know where she finds all these viruses