Ubisoft's Assassin's Creed 2 has a new DRM system that requires you to be online all the time when you're playing the game. If you lose connection at any point then it will stop the game, lose your progress and refuse to allow you to continue without it reconnecting. All your save game data is kept on the remote server so if you lose the connection then it can't save.
The limited activation systems that exist in other games is pretty bad already but this is just stupid. If you don't have an always on connection at home then you're screwed. If your internet goes down for any reason then you're screwed. If you travel with a laptop and therefore don't have an always on connection then you're screwed. If you're posted abroad by the military or as a job without an unrestricted internet connection then again, you're screwed.
They also restrict you from reselling the game by linking it all to your online account.
How long before a game cracker reverse engineers the protocol and creates a server you can run yourself? All this DRM does is drive people who legitimately own the game nuts.