Alright, so I have missed out on two jobs recently due to two questions in particular, so I thought I would share my experience and what I might do better next time and then invite everyone to do the same.
1. This was a local job with a chemical company fortune 500 level, local systems admin, I felt like I was at a disadvantage because I didn't have enterprise level Vmware experience and enterprise storage experience, I.E. San.
Question: what is your biggest downfall or what is the thing most wrong with you?
This is a question I don't have a good track record with, because I have tried to be completely honest and most people don't interpret the honest answer well, the real answer is I run, run, run, If I am not working then I am out playing (poker, shooting pool, dating, traveling etc) I don’t always let myself rest as much as I could. I feel like this answer may have been the kiss of death for me in this particular interview.
Solution: I will answer this question with; I am a perfectionist; which is true to some extent I am hard on my self and have high expectations whenever I take on a task; even if the task only warrants a quick and dirty solution; I usually lean towards wanting to implement a ten year solution; what can I say I believe in scalability.
2. This was a job I really wanted in Las Vegas as a windows system administrator again I felt like I was at a disadvantage because I don't have experience with Storage area networks (I understand the concepts and could spec out a solution and order all the right equipment, but have never been hands on or implemented it).
Questions:
1. The interviewer started by asking me to tell him a little about my self, I have been working in IT for five years and worked up from consulting work to mid level admin to my last post as a senior level admin.
I have been hit with this question several times and feel like this is a normal question, but I haven't nailed it yet. During an interview you transition from so many different topics it's hard to give a concise answer that properly highlights your experience; while trying not to go off on a tangent.
(a lot of interviewers hate long winded answers, even to these mile wide questions, I have had several interviewers get frustrated when I give them the unabridged version; that’s what makes this question hard)
Solution: I plan to script an answer for this question and memorize the script or read directly from it for phone interviews, will also consider finding a book dealing specifically with IT interview's and maybe writing a book for interviewers; might make a million off that idea)
2. The kiss of death for this interview I believe was when I failed to answer one particular question, I feel like I nailed his AD FSMO roles, and group policy questions, and could semi answer the one SQL question he asked, also answered correctly his exchange question but wasn’t the exact answer he wanted,)
The question was if a user goes to an extremely large building what method would you use to dynamically assign a printer that is close to the user. This is unfortunately an area where I don’t have a ton of experience and I answered by assigning a script to that buildings site and have the printers map over to the users that way, the interviewer kept drilling and apparently my answer was incorrect, I respond well I haven’t had a lot of experience networks that geographically dispersed, this frustrates me because I could find the answer for this in ten minutes and implement it in a very short time, I KNOW I could.
So the recruiter gets their answer today, slinuxuzer does not have the necessary experience in enterprise environments and would not provide and immediate value to the team.
This sent me into orbit as I really wanted the job and feel like I got hit with some unlucky questions, granted they were legit and I couldn’t answer, but no one knows everything off the cuff and any good admin has to do research daily.
Solution

? You tell me? I guess I can work harder and research these specific questions I got hit with, but I work pretty damn hard at my profession spending 1k hours a year or more studying