One certainly nice change
Zero-downtime upgrade for VMware Tools – After you upgrade to the VMware Tools available with version 5.1, no
reboots will be required for subsequent VMware Tools upgrades.
http://www.vmware.com/files/pdf/products/vsphere/vmware-what-is-new-vsphere51.pdf
I am still annoyed how often VMWare is now being upgraded, some changes being quite big
New virtual machine format – New features in the virtual machine format (version 9) in vSphere 5.1 include
support for larger virtual machines, CPU performance counters and virtual shared graphics acceleration designed
for enhanced performance.
Can't wait for 100s of VMs with ghost nic issues