XP Pro Custom on an AD

Does anyone have any experience joining a custom install of XP Pro to an AD domain. I have read in a couple of places that it isn't possible but the explainations were vague and no work around except for reinstal with a fix was offered. Any help or pointers would be greatly appreciated. I am studing (again) for my 290 and would like to get this to work.
Life and the never ending pursuit....
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