I had an interview for an entry-level system admin position and the recruiter wasn't technical (pre-screening). She asked me broad questions that kind of caught me offguard. She asked if I knew distributed systems and infrastracture/application support.
I made a mistake of asking her to be more specific

I explained to her I needed to know about specific technolgoies involved. I believe this sounded I didn't know anything about these while I do.
My biggest problem is that every interview I go, I'm always faced with an area that I don't have practical experience, but know about it:
-Exchange
-SQL
-Programming
-Networking (CCNA, MCSE, Unix)
What skills are a 'must-know' for a system admin? Do I have to learn them all, after all each requires a lot of time, where to begin? I know a bit of everything, but more of networking.