esxcli network diag ping -I vmk2 -H 10.x.x.x
iSCSI port binding in ESX/ESXi 4.x and ESXi 5.x does not support routing. To resolve this issue and still use iSCSI port binding, you must place the iSCSI initiator and the iSCSI target on the same subnet. Alternatively, this can be resolved by disabling iSCSI port binding.